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Published research and ongoing clinical trials


Gathering postprandial breath data to overcome the drawbacks of single snapshot testing and enable more personalized and focused SIBO treatment.

Postprandial Breath H2 Using a Portable Handheld App-Connected Device to Predict the Presence of Small Intestinal Bacterial Overgrowth as well as the Response to Antibiotic Treatment.
Barahona C. et al. The American Journal of Gastroenterology. October 2021.

An independent external validation comparing AIRE to an existing breath hydrogen analyser for the diagnosis of lactose malabsorption.

Validity of a Portable Breath Analyser (AIRE) for the Assessment of Lactose Malabsorption. Shrestha A et al., Nutrients 2019.

AIRE was compared to the gold-standard clinical device to detect how well a particular carbohydrate was absorbed. There was 100% diagnostic agreement between the two devices.

A Pilot Validation Study Of An At-Home Hydrogen Breath Test Device. Gut. 2019; 68 (Suppl 2):A1–A269.

Breath testing in clinical practice

Breath testing is a non-invasive, cost-effective diagnostic tool used to evaluate a range of digestive conditions. It’s use is endorsed by the world’s leading gastroenterological organisations.


Breath testing represents an important, simple and safe test to diagnose carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO).

Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus 2017

We suggest the use of breath testing for the diagnosis of SIBO in patients with IBS...in symptomatic patients with suspected motility disorders...and in patients with constipation.

ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth 2020

Breath testing (lactulose and glucose) is...used to diagnose SIBO and appears to identify subjects likely to respond to treatment.

AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review 2020

Breath tests are non-invasive, relatively simple to perform and safe diagnostic tools, which can be used both in adults and in children. The results are considered helpful in the evaluation of common abdominal symptoms such as bloating, flatulence, abdominal pain, and diarrhea...

European guideline on indications, performance, and clinical impact of hydrogen and methane breath testing adult and pediatric patients 2022



Patients with a positive breath test are more than twice as likely to respond to treatment than those treated empirically. SIBO relapse is common, MedAIRE 2 makes retesting easy.

FoodMarble AIRE
FoodMarble AIRE


Those with methane-predominant SIBO are more likely to have constipation. Methane severity correlates to severity of constipation. Measuring methane enables more personalised treatment.

Food Intolerances

Food is perceived as a symptom trigger for 50-84% of IBS patients. Using MedAIRE 2 allows easy assessment of common food intolerances like fructose, lactose, inulin and sorbitol.

FoodMarble AIRE

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